The draw is out at the French Open and Marcos will open against fellow former Top 10 player Nicolas Almagro. Making his 12th appearance on the clay of Roland Garros, he has a favourable draw to go deep at the second Grand Slam event of the year.
Almagro, who suffered a knee injury last week in Rome, won their second round encounter at Roland Garros in 2012. But Marcos claimed their most recent meeting in Kuala Lumpur two years ago.
Should Marcos advance, he would face either 29th seed Juan Martin del Potro or qualifier Guido Pella. Del Potro has injury concerns as well, revealing shoulder and back ailments this week. Also in Marcos' section of the draw is top seed and World No. 1 Andy Murray, a potential third-round opponent.
Marcos' best result in Roland Garros came in 2007, when he reached the Round of 16.