Marcos will face former champion and ninth seed Rafael Nadal in a blockbuster clash at the Australian Open, after advancing to the second round on Tuesday.
Marcos won his opener at Melbourne Park after Mikhail Youzhny retired due to injury. He was leading 6-3, 3-0 when his Russian rival was forced to stop the match, which lasted 65 minutes.
On Thursday, Marcos will renew another rivalry against former World No. 1 Nadal, having faced off on nine previous occasions. His lone victory came in 2010 at the ATP World Tour Masters 1000 event in Cincinnati. They have not met in nearly two years.
Marcos will seek to continue a hot start to the season after reaching the semifinals last week in Auckland. He returns to the site of arguably his greatest result as a pro, having reached the Aussie Open final in 2006. In total, he owns a 25-12 record at the Grand Slam event.
Marcos returns to the court on Wednesday, opening his doubles campaign with Gilles Muller. They face the Taiwanese team of Cheng-Peng Hsieh and Tsung-Hua Yang. Marcos and Gilles reached the second round at the US Open.