The draw has been released for the 2016 Australian Open, with Marcos slated to open his campaign against Jo-Wilfried Tsonga on Monday.
A clash of former Australian Open finalists, Marcos finished runner-up in Melbourne Park in 2006, while Tsonga did so two years later. The Frenchman, seeded ninth, won all five of their previous encounters, but they've only met once in the last four years.
Should Marcos win, he would face either Australian wild card Omar Jasika or Ukraine's Illya Marchenko in the second round. Other seeds in his section of the draw include No. 7 Kei Nishikori, No. 17 Benoit Paire and No. 26 Guillermo Garcia-Lopez.
Marcos has appeared at the Australian Open more than any other Grand Slam, enjoying his greatest success there. A finalist in 2006, he has amassed a 24-11 record in 11 consecutive appearances and has set multiple records along the way. Marcos' nine five-set victories in Melbourne Park are second-most in tournament history. His legendary 2008 battle against Lleyton Hewitt stands as the latest finish in Grand Slam history, ending at 4:33am.
Marcos enters the first Grand Slam of the year having split two matches at the Kooyong Classic exhibition this week. He most recently beat Paul-Henri Mathieu in straight sets on Wednesday.